INVOLVEMENT OF p27CIP/KIP IN HSP25 OR INDUCIBLE HSP70 MEDIATED ADAPTIVE RESPONSE BY LOW DOSE RADIATION
نویسنده
چکیده
HANG-RHAN SEO, HEE-YONG CHUNG, YOON-JIN LEE, MIN BAEK, SANGWOO BAE, SU-JAE LEE and YUN-SIL LEE Laboratory of Radiation Effect and Laboratory of Radiation Experimental Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, 139-706, Korea, Department of Microbiology, College of Medicine, Hanyang University, Seoul 133-791, Korea Atomic Energy Policy Division, Atomic Energy Bureau, Ministry of Science and Technology, Gwacheon, Kyeonggi-Do, 427-715, Korea Corresponding author. E-mail : [email protected]
منابع مشابه
p27Cip/Kip is involved in hsp25 or inducible hsp70 mediated adaptive response by low dose radiation.
Thermoresistant (TR) clone of radiation-induced fibrosarcoma (RIF) cells have been reported to show adaptive response to 1 cGy of low dose radiation, and hsp25 and inducible hsp70 are involved in this process. In the present study, to further elucidate the mechanism of how hsp25 and inducible hsp70 regulate the adaptive response, hsp25 or inducible hsp70 overexpressed RIF cells were irradiated ...
متن کاملAdaptive Response Induced by Pre-Exposure to 915 MHz Radiofrequency: A Possible Role for Antioxidant Enzyme Activity
Background: Over the past few years, the rapid use of high frequency electromagnetic fields like mobile phones has raised global concerns about the negative health effects of its use. Adaptive response is the ability of a cell or tissue to better resist stress damage by prior exposure to a lesser amount of stress. This study aimed to assess whether radiofrequency radiation can induce adaptive r...
متن کاملAssessment of Adaptive Response of Gamma Radiation in the Operating Room Personnel Exposed to Anesthetic Gases by Measuring the Relative Gene Expression Changes Ku80, Ligase1 and P53
Background: Some operating room personnel are occupationally exposed to genotoxic agents such as anesthetic gases and ionizing radiation. Adaptive response, as a defense mechanism, will occur when cells become exposed to a low dose of factors harming DNA (priming dose), which in the subsequent exposure to higher dose of those factors (challenging dose), show more resistance and sensibility.. <b...
متن کاملAssessment of adaptive response of gamma radiation in the operating room personnel exposed to anesthetic gases by measuring the expression of Ku 80, Ligase1 and P53 genes
Introduction: Staffs of operating room are continuously exposed to anesthetic gases and ionizing radiation. Adaptive response, as a defense mechanism, will occur when cells become exposed to a low dose of factors harming DNA that causes in the next exposures to higher doses o...
متن کاملActivation of Radioadaptive Response via Injected Serum of Irradiated Rats with Low Doses of Ionizing Radiation
Introduction: One of the protective concepts in the interpretation of radiation damage in radiobiology is the radioadaptive response. The objective of this present report is to evaluate the induction of radioadaptive response in male rats by injection of pre-irradiated serum with low doses X-radiation intraperitoneally. Materials and Methods: 80 male adul...
متن کامل